what is ofc Frankly, there are different meanings OFC available out there and the usage of them completely depends on the situation and the thing you are doing. The generic and the most popular meaning of OFC is Of Course. Though the meaning of OFC can be different in different situations like there is a commercial term of OFC and that resembles the Offshore Financial Center. Also, if you are from the United States then you will have an Offsite Facilitation Center and that can also be said as OFC. As you can see there are different meanings of OFC and it depends on the usage to have the right meaning of this word.